About us

Lys Therapeutics, first-in-class biotherapies against neurological diseases


A breakthrough strategy to reverse blood-brain barrier leakage

Glunozumab program: development of a monoclonal antibody counteracting the neuroinflammatory and neurodegenerative processes implicated in the pathophysiology of neurological diseases by restoring the physiological function and integrity of the blood-brain barrier

Neuroimmunology strategy: counteracting neuroinflammation to tackle neurodegeneration

In the pathophysiology of ischemic stroke, multiple sclerosis and Parkinson’s disease, local glutamate levels induce an increased permeability of the blood-brain barrier via NMDA receptor-mediated signals, exacerbated by overexpressed endogenous tissue plasminogen activator (tPA) binding to the GluN1 subunit of NMDA receptors and triggering their overactivation.

As a result, intracellular calcium and nitric oxide levels increase. Matrix metalloproteinase and Rho-kinase are upregulated and phosphorylation of cytoskeleton and tight junction proteins results in their degradation. This elicits blood-brain barrier disruption, allowing immune cells to infiltrate the brain parenchyma.

This leads to neuroinflammation, a primary cause of neuronal cell death.

A unique mechanism of action: a CNS drug which does not need to cross the blood-brain barrier

Lys Therapeutics’ main drug-candidate is a first-in-class monoclonal antibody displaying a groundbreaking mechanism of action counteracting these mechanisms by specifically preventing inside blood vessels the binding of tPA on the GluN1 subunit of NMDA receptors, without blocking the physiological function of NMDAr.

By inhibiting this interaction, NMDAr can operate normally, haltering downstream deleterious cellular pathways. Tight junctions are reestablished, endothelial cells return to their healthy state and the blood-brain barrier function is restored, protecting the brain from further neuroinflammatory and subsequent neurodegenerative cascades.

Created with BioRender.com

Scientific publications:


Monoclonal antibody targeting the restoration of NMDAr function

Meet our team

Dr. Manuel BLANC, PhD, MBA

Co-founder, Chief Executive Officer, President of the Strategic Committee



Co-founder, Chief Financial & Development Officer, member of the Strategic Committee

Pr. Denis VIVIEN, PhD, PU-PH

Chief Scientific Officer, President of the Scientific Advisory Board


Engineer, R&D

Dr. Jean-Baptiste BERTRAND, PhD

Head of Clinical Operations

Dr. Nathalie DELETAGE, PhD

Senior Program Manager, Preclinical R&D

Dr. François FOSSIEZ, PhD

Head of CMC

Dr. Jordan GUYON, PharmD

Chief Operating Officer

Dr. Flavie LESEPT, PhD

Program Manager, Preclinical R&D

Dr. Fanny POTZEHA, PhD

Project Manager, Preclinical R&D


Head of IT and data protection

Strategic Board


Member of the Strategic Board

Dr. Pierre MORGON, PharmD, LL.M, MBA

Member of the Strategic Board

Philippe BISSAY, MBA

Member of the Strategic Board

Dr. Thibault HONEGGER, PhD

Member of the Strategic Board

Scientific Advisory Board

President of the SAB: Pr. Denis Vivien (PhD, PU-PH), France, co-inventor of Glunomab & expert of tPA, head of the Research Institute “Blood and Brain @ Caen-Normandie”

Pr. Diederik DIPPEL (MD, PhD), the Netherlands, neurologist, co-director of Erasmus Medical Center, Rotterdam

Pr. Joan MONTANER (MD, PhD), Spain, neurologist, head of Neurovascular Research at the Vall d’Hebron Research Institute

Pr. Richard Macrez (MD, PhD), France, co-inventor of Glunomab, Professor and emergency physician, head of the Emergency Unit at Caen-Normandie Hospital

Dr. Désiré COLLEN (MD, PhD), Belgium, inventor of rtPA (alteplase) still the most effective drug for thrombolytic therapy of acute myocardial infarction and ischemic stroke

Pr. Yannick BÉJOT (MD, PhD), France, neurologist, head of Neurology at Dijon-Bourgogne hospital

Via BB@C Institute:  Pr. Eng Lo (MD, PhD), USA, neurologist, Professor of Neurology and Radiology, Harvard Medical School, and Research Staff, Massachusetts General Hospital

Via BB@C Institute: Pr. Martin Dichgans (MD, PhD), Germany, neurologist, Director of the Institute of Stroke and Dementia Research (Medical Center of the University of Munich), head of the World Stroke Organization



We don’t have open positions at the moment, but stay tuned!

Contact us

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Main offices: Lyon, France

56 rue Saint-Jean-De-Dieu

69007 LYON, France

Labs: Caen, France

Cyceron, Boulevard Henri Becquerel
Campus Jules Horowitz
14000 CAEN, France