About us

Lys Therapeutics, first-in-class biotherapies against neurological diseases

Meet our team

Dr. Thibault HONEGGER, PhD

Co-founder, member of the Strategic Committee

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Philippe DUJARDIN

Co-founder, head of Finance, member of the Strategic Committee

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Dr. Manuel BLANC, PhD, MBA

Co-founder, CEO, President of the Strategic Committee

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Dr. François FOSSIEZ, PhD

Head of CMC

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Dr. Flavie LESEPT, PhD

Project Manager, Preclinical R&D

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Pr. Denis VIVIEN, PhD, PU-PH

Head of Science, President of the Scientific Advisory Board

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Werner KLINGER

Head of IT and data protection

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Dr. Manuel BLANC

Dr. Manuel BLANC

PhD, MBA

Co-founder, CEO, President of the Strategic Committee

Dr. Thibault HONEGGER

Dr. Thibault HONEGGER

PhD

Co-founder, member of the Strategic Committee

Philippe DUJARDIN

Philippe DUJARDIN

Co-founder, member of the Strategic Committee

Pr. Denis VIVIEN

Pr. Denis VIVIEN

PhD, PU-PH

President of the Scientific Advisory Board – acting CSO

Dr. François FOSSIEZ

Dr. François FOSSIEZ

PhD

Head of CMC

Dr. Flavie LESEPT

Dr. Flavie LESEPT

PhD

Project Manager, Preclinical R&D

Werner KLINGER

Werner KLINGER

Head of IT and data protection

Scientific Advisory Board

President of the SAB: Pr. Denis Vivien (PhD, PU-PH), France, co-inventor of Glunomab & expert of tPA, head of the Research Institute “Blood and Brain @ Caen-Normandie”

Dr. Richard Macrez (MD, PhD), France, co-inventor of Glunomab, assistant professor and emergency physician, head of Emergency Unit at Caen-Normandie Hospital

Dr. Désiré COLLEN (MD, PhD), Belgium, inventor of rtPA (alteplase) still the most effective drug for thrombolytic therapy of acute myocardial infarction and ischemic stroke

Pr. Diederik DIPPEL (MD, PhD), the Netherlands, neurologist, co-director of the Erasmus University MC Stroke Center

Pr. Yannick BÉJOT (MD, PhD), France, neurologist, head of Neurology at Dijon-Bourgogne hospital

Pr. Joan MONTANER (MD, PhD), Spain, neurologist, head of Neurovascular Research at the Vall d’Hebron Research Institute

Via BB@C Institute: Pr. Martin Dichgans (MD, PhD), Germany, neurologist, Director of the Institute of Stroke and Dementia Research (Medical Center of the University of Munich), head of the World Stroke Organization

Via BB@C Institute:  Pr. Eng Lo (MD, PhD), USA, neurologist, Professor of Neurology and Radiology, Harvard Medical School, and Research Staff, Massachusetts General Hospital

Science

An outstanding scientific background

Gluno(zu)mab® : a monoclonal antibody counteracting the strong toxicity triggered by the interaction
of an endogenous protease, tissue plasminogen activator (tPA) with NMDA receptors (NMDAr)

Gluno(zu)mab® immunotherapy: a groundbreaking mechanism of action:

In the pathophysiology of neurological diseases such as stroke, multiple sclerosis as well as many other neurodegenerative disorders, one protease called tissue plasminogen activator (tPA) is triggering off-target toxicity via the binding to NMDA receptors (NMDAr) present on vascular endothelial cells and neurons, leading to its consequent hyperactivation and causing deleterious increase of the permeability of the blood brain barrier, as well as strong neuroinflammation and excitotoxicity.

By blocking the tPA-NMDAr interaction, Gluno(zu)mab® counteracts this tPA-dependent strong toxicity, without interfering with basal NMDAr functioning.

A systemic drug treatment for CNS pathologies:

  • Target : NMDA receptors (NMDAr) present on vascular endothelial cells (within the blood vessels)
  • Strong advantage : no need to cross the blood brain barrier (BBB) to act on the central nervous system (CNS)

A very high specificity:

  • The epitope is only present on NMDA receptors, not on any other proteins

A well-known and fully understood mechanism of action:

  • MoA: antagonism of tPA-NMDAr interaction in the blood vessels, leading to restoration of NMDAr basal functioning (no perturbation of NMDAr).

Therapeutic effects on blood brain barrier permeability and associated neuroinflammation and excitotoxicity

Scientific publications of Lys Therapeutics and Pr. Denis Vivien et al.:

Pipeline

Clinical development of Gluno(zu)mab®

Newsroom

Career

We don’t have open positions at the moment, stay tuned!

Contact us

Headquarters: Caen, France

Campus Jules HOROWITZ
Cyceron, Boulevard Henri Becquerel,
14000 CAEN, France

Main offices: Lyon, France

LYON, France